Endocrine Abstracts

Obesity is characterized by insulin resistance and pancreatic β-cell dysfunction; moreover, secretion of adipokines from adipocytes may affect metabolic functions in several tissues, including pancreatic β-cells. Extracellular vesicles (EVs), released by cells as exosomes or shedding vesicles, play a key role in cell-to-cell communication, modifying the phenotype and function of recipient cells by delivering proteins, RNAs and microRNAs. The crosstalk between adipocy...

Since its first description in 2000, Longitudinal Gastrectomy (LG) has become the first surgical procedure in the treatment of morbid obesity in the world, exceeding in numbers Gastric Bypass (GB). GB is considered to have better results regarding long-term weight loss and improvement in co-morbidities. We aimed to demonstrate that LG is non inferior to GB for a composite end point that included more than 50% excess weight loss from the baseline and surgery related complicatio...

Background: Increased cortisol levels in obesity may contribute to the associated metabolic syndrome. In obesity, the activated innate immune system leads to increased interleukin (IL)-1β, which is known to stimulate the release of adrenocorticotropin hormone (ACTH). We therefore hypothesised that in obesity IL-1 antagonism would result in downregulation of the hypothalamo-pituitary-adrenal (HPA) axis, leading to decreased cortisol levels.Methods: I...

Background and Aims: Non-alcoholic fatty liver disease (NAFLD), a leading cause of cirrhosis and liver cancer, is increasing worldwide due to rising obesity rates, particularly in Asia. Weight loss induced with diet and exercise decreases hepatic steatosis and inflammation, but requires greater efforts to sustain compared to medication. We therefore aimed to compare the effects of liraglutide, a glucagon-like peptide-1 agonist which induces weight loss, on hepatic steatosis an...

Introduction: Constitutional thinness (CT) is an underweight state characterized by normal menstruations and no change in feeding behaviour. Thinness is the only resemblance between Anorexia Nervosa (AN) and CT. Removal of amenorrhea in the new DSM 5 definition of AN might lead to misdiagnosis between these two populations. The objective of this study was to compare CT, AN and Control subjects in terms of biological, anthropometric, and psychological markers in order to better...