Endocrine Abstracts

Context: Since the exact cause of type 1 diabetes mellitus (T1DM) remains unclear, the detection of novel biomarkers is necessary to complement the information obtained from the presence of autoantibodies together with genetic and environmental risk factors. MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that negatively regulate gene expression. Changes in their expression were described in several pathological conditions, including autoimmune diseases. Circul...

The aim: To evaluate effectiveness of complex therapy in patients with comorbidity of type 2 diabetes (DM2) and essential hypertension (EH) depending on genetic polymorphism peroxisome proliferator-activating receptor-γ2 (PPARγ2). Before and after 3 months of treatment we examined 145 patients with EH stage II, grade and DM2 moderate, subcompensated aged 45–60 years: group 1 (71 patients) received standart therapy (telmisartan, indapamide, metformin, gliclazide,...

Promiscuous multi-agonists that simultaneously activate two or three key receptors (incretin- and/or glucagon receptor) were recently shown to improve glycemic control in mice. Here we investigated the underlying mechanisms of multi-agonists to enhance insulin secretion in murine islets and human pancreatic β-cells. These mixed agonists display a greater potency in cAMP signaling as compared to the native incretins. However, pharmacological blockade of cAMP signaling only...

Background: Probiotics have beneficial effect on obesity related disorders in animal models. Despite a large number of animal data, randomized placebo-controlled trials (RCT) concluded that probiotics have a moderate effect on glycemic control-related parameters. However, effect of probiotics on insulin resistance are inconsistent.Aim: In a double-blind single center RCT, effect of alive multistrain probiotic vs placebo on insulin resistance in type 2 di...

Background: Diabetic kidney disease (DKD) is the main cause of end-stage renal disease It is defined by glomerular filtration rate (GFR) impairment and/or presence of increased urinary albumin excretion (UAE). However, these parameters are nonspecific and somewhat delayed manifestations of renal damage. Thus, earlier DKD new biomarkers are strongly warranted.Objective: To investigate the urinary peptidomics profile of type 2 diabetes mellitus (DM) patien...