Endocrine Abstracts

Evaluation of bone quality represents a challenge since the analysis by bone mineral density (BMD), provides useful but incomplete information. New tools are arising, and amog them, TBS is emerging as a new surrogate marker of bone texture and microarchitecture which may be useful to potentially evaluate the risk of bone fracture and can be obtained from already existing BMD scans. Retrospective study of 23 patients with PHH. Clinical, analytical and BMD data were collected form clinical records. TBS was calculated by reevaluating the already existing BMD images. Patients were classified into two different groups according to their treatment: 1) 13 patients who underwent surgery, in whom TBS was evaluated before surgery (B-S) and one year after surgery (A-S), and 2) 10 patients who received standard medical treatment, in whom TBS was evaluated with a time-lapse of 1 year. Basal age, body mass index (BMI), serum calcium, vitamin 25-OH-D levels and T-Scores were not significantly different between the two groups. Only PTH levels (82 vs 110 pg/ml, P=0.04) presented differences. We observed a significant improvement of TBS one year after surgery in the first group (1.244± 0.11 vs 1.311±0.1 P=0.08). A subtle deterioration on TBS was observed one year after standard treatment in the second group (1,249±0.06 vs 1.223±0.07 P=0.124). Overall, surgical patients experienced a TBS increase 5.8% whilst a decrease of −2.04% was observed in the second group (P=0.02). In the multivariate correlation analysis, the percentage of variance in TBS was negatively correlated with the level of PTH and calcium at the moment of the second BMD (0.04 and 0.03 respectively). Bone microarchitecture, measured by TBS, improves after surgery in patients with PHH and has shown to be sensitive to changes developed during only one year time-lapse in bone. This parameter is a promising tool in the evaluation of bone status in PHH.