Endocrine Abstracts

Survival rates of childhood cancer have improved markedly and today more than 80% of those diagnosed with a pediatric malignancy will become 5-year survivors. Nevertheless, survivors exposed to cranial radiotherapy (CRT) are at particularly high risk for long-term morbidity, such as endocrine insufficiencies, metabolic complications and cardiovascular morbidity. Deficiencies of one or more anterior pituitary hormones have been described following therapeutic CRT for primary brain tumours, nasopharyngeal tumours, and following prophylactic CRT for childhood acute lymphoblastic leukemia (ALL). Studies have consistently shown a strong correlation between the total radiation dose and the development of pituitary deficits. Further, age at treatment and also time since treatment has strong implications on pituitary hormone deficiencies. Studies have shown that childhood cancer survivors (CCS) need information regarding psychosocial support and social advocacy. Thus, the challenge is to guide the survivors through the potential late complications and offer care designed to meet their specific needs in order to optimise their quality of life. Information about late complications is essential in order to achieve an independent life and to engage in healthy behaviour, such as regular physical activity. Thus, having a holistic approach, tailored to their specific needs is crucial for their future well-being and quality of life.