Endocrine Abstracts

Introduction: Thyroid hormones play a central role in the regulation of the cardiovascular system. Heart failure with preserved ejection fraction (HFpEF) is responsible for more than 50% of all heart failure cases and its main pathophysiological alteration is diastolic dysfunction. Diminished thyroid function is known to predominantly impair diastolic function, however the thyroid hormone status in HFpEF remains largely unknown.Methods: We evaluated an a...

Signal transducer and activator of transcription 6(STAT6) is involved in epithelial cell growth. However, little is known regarding the STAT6 phosphorylation status in Graves’ disease (GD) and its role in thyroid epithelial cells (TECs). In this study, we found that STAT6 phosphorylation (p-STAT6) was significantly increased in TECs from both GD patients and experimental autoimmune Graves’ disease mice and that STAT6 deficiency ameliorated GD symptoms. Autocrine IL-4...

Background: Delayed thyroid-stimulating hormone (TSH) recovery during treatment of Graves’ disease is caused by long-term excessive thyroid hormone, which results in down-regulation of pituitary thyrotropic cells. However, it is unknown whether delayed TSH recovery exists after levothyroxine (LT4) dose adjustment in patients with differentiated thyroid cancer (DTC) who are taking a suppressive dose of LT4.Methods: We retrospectively reviewed 97 DTC ...

Introduction: In the etiology of thyroid dysgenesis (TD) an interplay between genetic and environmental factors is thought to play a crucial role. Data from previous studies on association between the season of birth and the incidence of TD causing congenital hypothyroidism (mainly agenesis and ectopy) are conflicting. To date, seasonality of births have not been analysed yet in regard to congenital absence of one thyroid lobe (thyroid hemiagenesis, THA).<p class="abstext"...

Purpose: Skeletal muscle has been recognized as a thyroid hormones (THs) target for contractile function, regeneration, metabolism and glucose disposal. Despite a role in regulating muscle development has been described, little is known about the role of THs in regulating muscle homeostasis in a pathological state such as food deprivation induced atrophy. The purpose of this study is to evaluate whether thyroid hormones may hamper the fasting induced skeletal muscle atrophy an...

Introduction: Calcium replacement after Thyroid surgery has been changing along times. The aim for this replacement is to avoid hypocalcaemia effects after thyroid surgery but not all the patients seem to need it. Parathyroid hormone (PTH) has a short half-life after its release into the bloodstream, making it a good marker of calcium metabolism in short time after surgery.Method: Prospective study of Endocrine Surgery Multidisciplinary group of one Cent...

Endogenous TH metabolite 3-iodothyronamine (T1AM) and recently developed thyronamine-like synthetic analogues SG1 and SG2 have emerged as neuroprotective agents. Autophagy has proved to be an effective therapeutic approach for neurodegenerative diseases. Therefore we investigated whether these compounds can induce autophagy in human glioblastoma cells (U-87MG).Cultured U-87MG cells were initially treated with 1 μM T1AM, SG-1, SG-2 or vehicle for 30&...

Products of carbohydrates, proteins and lipids hydrolysis are absorbed by specific carriers located at the enterocytes apical membrane, but little is known about the mechanisms related to their regulation by own nutrients, especially considering the high consumption of fats. Carbohydrates are transported by SGLT1, GLUT5 and GLUT2 and peptides are transported by PEPT1. Cholesterol is transported by NPC1L1 and long chain fatty acids occur through FAT-CD36 and FATP4. Thyroid horm...