ECE2017 Guided Posters Thyroid 1 (9 abstracts)
Cardiovascular risk factors in patients with autoimmune thyroiditis
João Sérgio Neves 2 , Catarina Cunha 1 , Celestino Neves 2 , Sofia Castro Oliveira 2 , Oksana Sokhatska 3 , Camila Dias 4 , César Esteves 2 , Miguel Pereira 2 , José Luís Medina 1 , Luís Delgado 3 & Davide Carvalho 1,
1Faculty of Medicine, University of Porto, Porto, Portugal; 2Endocrinology Service, São João Hospital, Faculty of Medicine, University of Porto, Porto, Portugal; 3Immunology Department, São João Hospital, Faculty of Medicine, University of Porto, Porto, Portugal; 4Department of Biostatistics and Medical Informatics, Faculty of Medicine, São João Hospital, University of Porto, Porto, Portugal; 5Instituto de Investigação e Inovação em Saúde, Faculty of Medicine, University of Porto, Porto, Portugal.
Background: Overt thyroid dysfunction is associated with an increased cardiovascular risk. The impact of subclinical hypothyroidism and autoimmunity in the increased cardiovascular risk remains controversial. Aim: To evaluate the interrelations between thyroid function, thyroid autoimmunity and cardiovascular risk factors, in patients with autoimmune thyroiditis (AIT).
Methods: 353 subjects with AIT were evaluated. We defined three groups based on TSH levels: TSH<2.5 μUI/ml, TSH 2.5–5.0 μUI/ml and TSH>5.0 μUI/ml. We recorded thyroid function tests, thyroid autoimmunity, insulin resistance markers including Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), lipid profile, homocysteine, C-reactive protein (CRP) and vitamin B12 levels. Statistical analysis was performed using Kruskal-Wallis test and Spearman correlations.
Results: Our sample comprised 94% females with a mean age of 47±16.3 years. The group TSH>5.0 μUI/ml presented higher levels of HOMA-IR when compared to the other two groups [2.96(1.76–4.59) in TSH>5.0 μUI/ml vs 1.86(0.97–2.56) in TSH 2.5–5.0 μUI/ml and 1.58(1.06–2.46) in TSH<2.5 μUI/ml, P=0.002]. In the total group we observed positive correlations between free T3 (FT3) and both HDL (r=0.118, P=0.028) and ApoA1 (r=0.129, P=0.024); TSH was positively correlated with HOMA-IR (r=0.146, P=0.018) while free T4 (FT4) was negatively correlated with homocysteine (r=−0.119, P=0.041). In the group TSH<2.5 μUI/ml, positive correlations were found between TSH and both HDL (r=0.136, P=0.031) and homocysteine (r=0.147, P=0.028), FT4 and CRP (r=0.136, P=0.037) and also anti-thyroglobulin and ApoB (r=0.165, P=0.013); anti-thyroglobulin was negatively correlated with homocysteine (r=−0.186, P=0.006). Negative correlations between anti-thyroglobulin, total cholesterol (r=0.371, P=0.004), LDL (r=−0.325, P=0.011), ApoB (r=−0.342, P=0.022) and lipoprotein(a) (r=−0.470, P=0.001) were revealed in the group TSH 2.5–5.0μUI/ml. Regarding the group TSH>5.0 μUI/ml, we found positive correlations between FT3 and HDL (r=0.358, P=0.030), vitamin B12 (r=0.398, P=0.024) and HOMA-IR (r=0,424, P=0,031); and between anti-thyroglobulin and homocysteine (r=0.383, P=0.033).
Conclusion: We observed significant correlations between thyroid function, thyroid autoimmunity, insulin resistance, lipid profile and homocysteine that may contribute to an increased cardiovascular risk in AIT.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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