Endocrine Abstracts

Aim: Olfaction and gustation have great importance on feeding behavior and food preferences. Recent published data suggests that olfaction and taste functions are modulated in response to changing levels of various molecules such as ghrelin and leptin which are play important roles on feeding and energy balance. We aimed to investigate the olfaction and taste functions in obese female patients and the association between serum ghrelin and leptin levels compared with healthy co...

Objective: Sarcopenic obesity is a double burden for older people because it carries the cumulative risk of functional abnormality, metabolic, cardiovascular risk, and mortality compared to either sarcopenia or obesity alone. Diabetes is related to an increase in visceral adiposity and is associated with the risk of sarcopenia. The objective was to explore the association between sarcopenic obesity and diabetes and determine the associated factors with sarcopenic obesity in ol...

The ingestion of high-fat diet has been considered a crucial factor in the genesis of subclinical systemic inflammation and insulin resistance. The resistance training (RTr) can be an effective tool for the prevention and treatment of immune-metabolic disorders through physiological and morphological adaptations. The purpose of the present study was to analyze the effects of RTr and cessation of training on muscle inflammation and expression of genes related to glucose metabol...

Obesity is one of the major causes of morbidity and mortality worldwide and is considered a risk factor for metabolic syndrome, type 2 diabetes and cardiovascular disease (CVD). miRNAs are epigenetic regulators of several aspects of metabolism and energy homeostasis and are involved in obesity and regulation of insulin sensitivity. miR 26b is among the obesity-related micoRNAs and is differentially expressed in preadipocytes and mature adipocytes in humans and is upregulated d...

Background: The association between fat mass and obesity-associated gene (FTO) polymorphism rs 9939609 and obesity was found in some European countries. However, the data concerning Polish population is insufficient. The relationship between FTO and metabolic disorders remains unclear.Methods: The study group consisted of 686 women and 418 men from Lower Silesia in Poland, aged 30–80 years (mean age 54.2±9.26 years). The examination included an...

Anti-obesity therapeutics based on increasing the amount of brown fat have received more attention from industry as the biology and regulation of brown fat are better understood than that of beige fat. Cold exposure and treatment with β3 adrenergic receptor agonist are known to activate brown/beige adipose tissue. Many transcriptional pathways regulating brown/beige adipose tissue have been identified, the role of lipid biosynthetic enzymes in brown/beige adipose tissue h...

Sex steroids are involved in the development of obesity and metabolic disorders. The interrelationship between sex steroid balance and metabolism is complex, and the underlying mechanisms are still unclear. The impact of gut microbiota in development of obesity, inflammation and metabolic dysregulation has been suggested in humans and demonstrated in mouse models. Less is known about the interactions between sex steroids and gut microbiota. Based on available evidence, it is, ...

Introduction: The chronic reduction of sleep duration is associated to an increased risk of weight gain, but mechanistic aspects remain to be fully elucidated. The aim of our study was to examine the relationship between short sleep duration and energy metabolism, fuel selection and energy balance in overweight and obesity. Methods: Inclusion criteria were: age 18–65 years, BMI ≥25 kg/m2. Use of any CNS medications, any psychiatric disorders and night shi...

Background: Harmful effects of mercury on cardiovascular disease have been suggested in many epidemiologic studies. However, reports on harmful effect of mercury in relation to overweight or obesity have shown inconsistent findings.Methods: A total of 1577 children and adolescents (10–18 years of age) from the Korean National Health and Nutrition Examination Survey (KNHANES) 2009–2013. Overweight or obese group was defined as over the 85th perc...

Aim: To investigate the possible association of the rs9939609 polymorphism in the FTO gene with obesity in the Republic of Tatarstan (RT).Materials and methods: The study involved 63 adult patients (21 men and 42 women; 38–77 years old) with overweight or obesity and 515 healthy young people (157 men and 358 women; 16–35 years old) with normal weight. We assessed clinical and biochemical parameters (blood lipid profile). The analysis of the rs9...

Objective: The aim of this meta-analysis is to evaluate the effect of bariatric surgery on sexual function and sex hormone levels in obese patients.Methods: Two independent investigators conducted a literature search of PubMed, Medline and Cochrane databases using the terms bariatric surgery, sexual function and sex hormone to identify appropriate human studies published in English about the effect of bariatric surgery on sexua...

3-Iodothyronamine (T1AM) is a hormone like molecule structurally similar to TH, that has been reported to modulate energy metabolism by favoring lipid over glucose catabolism. To better understand the role played by T1AM on the regulation of lipid metabolism, in the present study we administered spontaneously obese mice with T1AM at two different dosages (10 and 25 mg/kg per day) for 7 days and the effects on body weight (BW) and lipid profiles were examined. In addition a flu...