ECE2017 Guided Posters Female Reproduction (12 abstracts)
Nonalcoholic fatty liver disease liver fat score (NAFLD-LFS) could be used for the assessment of NAFLD in women with PCOS
Jelica Bjekic-Macut 1 , Ivana Bozic-Antic 2 , Konstantinos Tziomalos 3 , Dusan Ilic 2 , Danijela Vojnovic-Milutinovic 4 , Olivera Stanojlovic 5 & Djuro Macut 2
1CHC Bezanijska kosa, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Department of Medicine, University of Thessaloniki, Thessaloniki, Greece; 4IBISS, University of Belgrade, Belgrade, Serbia; 5Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: A relation between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) was demonstrated recently. Both NAFLD and PCOS are associated with increased risk for type 2 diabetes and cardiovascular disease. NAFLD liver fat score (NAFLD-LFS) has been implicated as a non-invasive surrogate marker for NAFLD. The aim of this study was to identify the prevalence of NAFLD in different PCOS phenotypes using NAFLD-LFS.
Methods: We evaluated 489 obese PCOS women (PCOS: 33.2±5.7 kg/m2; 25.6±6.2 years) diagnosed using ESHRE/ASRM criteria and 97 BMI-matched obese healthy women (controls: 32.5±5.5 kg/m2; 31.7±5.1 years). PCOS group was divided into 4 phenotypes: A [anovulation (ANOV), hyperandrogenism (HA), polycystic ovary morphology (PCOM)], B (ANOV,HA), C (HA,PCOM) and D (ANOV,PCOM). NAFLD was assessed using NAFLD liver fat score (NAFLD-LFS) cutoff > −0.640. Differences between groups were age adjusted.
Results: NAFLD was more prevalent in PCOS in comparison to controls (59.7 vs 44.4%, P=0.009). Our PCOS group consisted of 268 women with phenotype A, 129 with phenotype B, 47 with phenotype C and 35 with phenotype D. Prevalence of NAFLD in phenotypes were: A: 59%, B:61%, C:53% and D:66%. There were significant differences in the prevalence of NAFLD between controls and phenotype A (P=0.015), phenotype B (P=0.015) and phenotype D (P=0.028). There were no significant differences between phenotypes.
Conclusions: NAFLD is more prevalent in obese PCOS women than in obese BMI-matched controls. All four phenotypes have the same risk for NAFLD which confirms susceptibility of PCOS as a whole to develop metabolic derangements.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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