Endocrine Abstracts

Objective: To evaluate the relation of mean platelet volume (MPV) levels with serum paraoxonase-1 activity in diabetic patients with respect to obesity and diabetic complications.

Methods: A total of 201 diabetic patients grouped with respect to obesity obese (n=89) and non-obese (n=112) and diabetic complications with (n=50) or without (n=150) microvascular complications and with (n=91) or without (n=108) macrovascular complications groups were included. Data on demographic and lifestyle characteristics of patients, anthropometric measurements, diabetes related microvascular and macrovascular complications, Correlation of MPV values to paraoxonase and arylesterase activities.

Results: Mean(SD) paraoxonase and arylesterase values were 119.8±37.5 U/l and 149.0±39.9 U/l, respectively in the overall population, with no significant difference with respect to obesity and macrovascular diabetic complications, whereas significantly lower values for paraoxonase 107.5±30.7 vs. 123.9±38.8 U/l, (P=0.007) and arylesterase 132.1±30.2 vs. 154.±41.2 U/l (P=0.001) were noted in patients with than without diabetic microvascular complications. Mean(SD) MPV values were 9.10±0.87 fL in the overall population, with no significant difference with respect to obesity and diabetic complications. No significant correlation of MPV values to paraoxonase and arylesterase activities. A significant positive correlation was determined with plasma 25-(OH) hydroxyvitamin D3 levels (r=0.398, P=0.001 and r=0.484, respectively P=0.001). HOMA-IR exhibited a significant negative correlation with PON and arylesterase in the groups.

Conclusion: In conclusion, our findings revealed a significant decrease I PON-1 activity in diabetic patients with microvascular rather than macrovascular complications, whereas regardless of obesity and diabetic complications, no increase in thrombogenic activity and no relation of thrombogenic activity with PON-1 activity. PON-1 activity exhibited a significant negative correlation, independent of obesity, sex and age, with plasma glucose, HbA1c and HOMA-IR values in all patients and a significant positive correlation with 25-OH vitamin D3 values. Low PON-1 activity and 25 OH vitamin D3 levels may be a marker of inadequate glycemic control independent of obesity in diabetic patients They may play an important role for early atherosclerosis who had only in obese diabetic especially microvascular diabetic complications well glysemic control of the most factor that it prevents diabetic complications and also well glysemic control and apropiate vitamin D levels have good affect on diabetic complications.