ECE2017 Guided Posters Diabetes & complications 1 (12 abstracts)
Carbohydrates metabolism and H. pylori: case-control study
Isabel Ma Cornejo-Pareja 1 , M Mar Roca-Rodríguez 2 , Leticia Coín-Aragüez 3 , Araceli Muñoz-Garach 1 , María Molina-Vega 1 , Cristina Díaz-Perdigones 1 , Carmen Hernández-García 1 , Juan Alcaide-Torres 3 , Carlos Clu-Fernández 1 , Laura Viñuela-González 4 , Laura Mora-Navas 4 , Isabel Mancha-Doblas 1 & Francisco J Tinahones-Madueño 1
1Endocrinology and Nutrition Department. Virgen de la Victoria Hospital, Málaga, Spain; 2Endocrinology and Nutrition Department Puerta del Mar Hospital, Cádiz, Spain; 3Research Laboratory IBIMA, Málaga, Spain; 4Microbiology Department, Virgen de la Victoria Hospital, Málaga, Spain.
Introduction: H. pylori infection has been related with extragastric diseases such as type 2 diabetes.
Aim: to evaluate changes in carbohydrate metabolism induced by 75g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori compared to healthy controls.
Materials and methods: A prospective case-control study. Biochemical parameters, carbohydrate profile, ghrelin and GLP1 levels before and after antibiotic eradication treatment were analyzed.
Results: We studied 40 cases and 21 controls (60% and 57.1% women, respectively). Mean age: 46,95±2,02 vs 44,52±2,73 years, family history of digestive disorders: 70% vs 57.1% and clinical history of gastrointestinal disease: 57,5% vs 42.9%, respectively. After antibiotic treatment, significant improvements in HbA1c (P=0,014), glucose levels post OGTT at 60′ and 120′ (P=0,018 and P=0,019, respectively) and HDL Cholesterol (P=0,021) were observed. Significant changes in basal ghrelin levels (P=0,05) were found, but C peptide levels did not change. We observed differences between infected population by H. pylori and healthy people: lower post OGTT insulin levels at 30′ and 60′ (P=0.042 and P=0.03, respectively) in infected patients. Those differences disappeared after treating the infection. In cases and controls, we found significant positive correlations in carbohydrate metabolism, and significant negative correlations in controls between ghrelin with basal insulin and C peptide. No significant correlations respect to GLP1 were found. 90% of patients completed correctly the treatment, 31,6% needed ranitidine and 97,5% eradicated H. pylori after conventional antibiotic treatment.
Conclusion: 1) H. pylori eradication improved carbohydrate metabolism. 2) Significant positive correlations in carbohydrate metabolism in cases and controls were found. 3) Negative correlations between ghrelin and pancreatic reserve were observed in cases. 4) Carbohydrate metabolism differences between healthy and infected people disappeared after eradication treatment. 5) More than 95% of patients achieved H. pylori eradication with conventional antibiotic treatment.
Volume 49
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Endocrine Abstracts
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