ECE2017 Guided Posters Bone & Calcium Homeostasis 1 (10 abstracts)
Fat mass distribution and resistin are independent predictors of bone mass in postmenopausal, but not premenopausal women.
Stefana Catalina Bilha 1, , Maria-Christina Ungureanu 1, , Petru Cianga 3, , Catalin Buzduga 1, , Adrian Aancute 1 , Valentin Zaharia 1 , Daniela Constantinescu 3, , Ecaterina Anisie 3 , Adrian Covic 5, & Dumitru Branisteanu 1,
1Endocrinology Clinic, “Sf.Spiridon” Hospital, Iasi, Romania; 2Endocrinology Department, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania; 3Laboratory of Immunology and Genetics, ”Sf. Spiridon” Hospital, Iasi, Romania; 4Immunology Department, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania; 5Nephrology Clinic, “Dr. C.I. Parhon” University Hospital, Iasi, Romania; 6Nephrology Department, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania.
Introduction: Body weight and lean mass (LM) are classic bone mass determinants. However, the association between total fat mass (FM), regional FM and bone remains controversial, especially as fat is a source of adipocytokines, with both positive and negative bone consequences.
Materials and methods: Anthropometric, bone mass (assessed by Dual X-Ray Absorptiometry; DXA) and body composition parameters (assessed by DXA) and also serum adipocytokine (leptin, adiponectin, resistin) levels were determined from 93 female volunteers (38 premenopausal and 55 postmenopausal women). Correlation analysis was performed in order to assess the association between body mass index (BMI), body composition parameters, adipocytokines and bone mass. Multivariable and hierarchical regression models were used to determine which of the above factors are independent predictors of bone mass.
Results: In correlation analysis, BMI, total LM, total FM and regional FM (trunk FM and lower limbs FM) were positively associated with bone mass in both groups. Correlations between adipocytokines and bone were found only in the postmenopausal group. In multivariable regression analysis, only LM remained an independent predictor of bone mass in premenopausal women, explaining 38.1% (P<0.001) of femoral neck, 24.5% (P=0.002) of total hip and 20% (P=0.005) of whole-body bone mineral density (BMD) variance; in postmenopausal women, LM, trunk-to-lower limbs FM ratio (together explaining 30.9% of the variance of total hip BMD, P<0.001) and resistin (adipokine known to regulate bone cell proliferation and bone turnover) remained independent positive predictors of bone mass. Hierarchical regression showed no additional effect of BMI or of total FM to that of total LM in predicting bone mass in both groups.
Conclusions: LM independently predicts bone mass in premenopause, while after menopause FM distribution becomes an important factor in regulating bone mass together with total LM and resistin. These parameters may find their place for fine tuning the evaluation of fracture risk.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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