ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Thyroid nodule size and the risk of malignancy
Entela Puca 1 , Ema Lumi 4 , Blertina Olldashi 2 , Sonila Bitri 1 , Dorina Ylli 3 , Agron Ylli 3 & Edmond Puca 3
1American Hospital 2, Tirana, Albania; 2Neo-Style Clinic, Tirana, Albania; 3UHC Mother Teresa, Tirana, Albania; 4Regional Hospital Teni Konomi, Korce, Albania.
Introduction: Thyroid nodule size is routinely assessed and has been a cause for concern, if it is a carcinoma or not.
Aim: Our aim was to evaluate the relationship between thyroid nodule size and cancer risk. It was a retrospective analysis of 386 patients with thyroid nodules who referred to surgery in our hospital from January 2011 to March 2016. Patient’s demographic data, nodules size, and final pathology were recorded. All data were analyses using SPSS18.
Results: From the total of 386 patients, female were 86% and male 14%, with mean age of 46.75 years old ±14.24 DS were included for this study. Based on final pathology 179 patients (46.5%) had malignant nodules. The mean size of malignant and benign nodules were 3.07±1.52 cm and 3.6±1.59 cm respectively (P<0.003). For the purposes of this investigation, thyroid nodules <1 cm in diameter provided baseline cancer risk for comparison (5.6% risk of cancer). The overall prevalence of cancer in nodules 1.0–1.9 cm was 20.1%; 2–2.9 cm was 30.8%; in nodules 3.0–3.9 cm, 23.4%; and in nodules ≥4.0 cm, 20.1%. The primary influence of this association was the low malignancy rate in nodules under 1.0 cm. When comparing nodules 1.0–1.9 cm, 2.0–2.9 cm, 3.0–3.9 cm, no difference in malignancy rate was demonstrated (P=0.5). For nodules >4 cm the differences was statistically significant (OD: 3.17; CI95%: 1.01–10.02; P<0.04).
Conclusion: These data provide strong evidence that thyroid nodule size >4 cm is associated with an increased risk (three fold) of well-differentiated thyroid cancer and can be applied in medical decision for thyroid surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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