Endocrine Abstracts

Columnar cell variant is rare variant of papillary thyroid carcinoma. It occurs in both genders with the most common occurence in the middle age of life. It differs from common PTC both in morphology and especially in biological behavior. The cancer cells also commonly harbor BRAF mutation. We describe a case of young women, who came for the examination of the thyroid gland before in vitro fertilization. We found normal thyroid function tests, negative antibodies. A small cystic lesion in the middle line of her neck under hyoid bone was seen at ultrasound. The small primary tumor in pyramid lobe of thyroid gland was found and cystic lesion was identified as the metastatic lymphonode. We scrutinized the genetic background of this more aggresive PTC variant and BRAF mutation was found. We mentioned the necessity of the differential diagnosis of cystic lesion of the neck. This case has happy end untill now thanks to early diagnosis.