ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Is thyroid imaging reporting and data system useful in prediction of malignancy in thyroid nodules with persistent nondiagnostic cytology?
Husniye Baser 1 , Oya Topaloglu 2 , Sevgul Faki 2 , Afra Alkan 3 , Mustafa Omer Yazicioglu 4 , Hayriye Tatli Dogan 5 , Reyhan Ersoy 2 & Bekir Cakir 2
1Ataturk Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey; 2Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey; 3Yildirim Beyazit University Faculty of Medicine, Department of Biostatistics, Ankara, Turkey; 4Yildirim Beyazit University Faculty of Medicine, Department of General Surgery, Ankara, Turkey; 5Yildirim Beyazit University Faculty of Medicine, Department of Pathology, Ankara, Turkey.
Introduction: Although malignancy rate is low in thyroid nodules with nondiagnostic (ND) cytology, it is reported as higher in persistent ND nodules. We aimed to determine the role of ultrasonography (US) features and Thyroid Imaging Reporting and Data System (TIRADS) in the prediction of malignancy in patients with persistent ND cytology.
Methods: 246 patients who underwent thyroidectomy with an indication of at least two ND cytologies were included in this study. Suspicious US features (solid component, hypoechogenicity, irregular margin, microcalcification, and taller-than-wide shape) and TIRADS categories (TIRADS category 3, 4a, 4b, 4c and 5) of each nodule were obtained from medical records.
Results: Of the 246 patients, 218 (88.6%) had benign and 28 (11.4%) had malignant final histopathology. Of these 28 patients with malignant histopathology, 25 (89.3%) were evaluated as papillary thyroid carcinoma, 1 (3.6%) as follicular thyroid carcinoma, 1 (3.6%) as medullary thyroid carcinoma, and 1 (3.6%) as undifferentiated thyroid carcinoma. Frequencies of taller-than-wide shape, solidity, hypoechogenicity, microcalcifications, and irregular margins were similar in benign and malignant groups (P>0.05, all). TIRADS categories of 246 nodules with ND cytology were as follows; 12 (4.9%) TIRADS 3, 53 (21.5%) TIRADS 4a, 104 (42.3%) TIRADS 4b and 77 (31.3%) TIRADS 4c. There was not any nodule with TIRADS 5 category. Malignancy rates of categories 3, 4a, 4b, and 4c nodules were 0, 13.2, 9.6 and 14.3%, respectively. No significant differences were found in TIRADS categories between benign and malignant nodules (P>0.05, all).
Conclusion: In the present study, malignancy rate was found as 11.4% in nodules with persistent ND cytology. There was not any suspicious US feature that was predictive for malignancy in ND nodules. Thyroid nodules in TIRADS 4a, 4b and 4c categories had higher malignancy rates than estimated risk of malignancy reported by the Bethesda system in ND cytology.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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