Endocrine Abstracts

52 years old man medicated with amiodaron 12 months, with laboratory confirmed hyperthyroidism, in us-examination 45 ml Basedow goiter, TRAb positive; ventricular tachycardia 180/min intermittent with sinusal tachycardia 120/min, thiamasol 120 mg i.v./daily, hydrocortisone 400 i.v. daily, crystalloids, beta blockers, diazepam, albumin. J131 scintigraphy – no iodine uptake. natriumperchlorate 1500 mg daily initially, continued next month 900 mg coused iodine uptake 17%. Finally -radioiodine 20 mCi, followed with thiamazole and steroids. After 4 weeks – euthyroid. 32 years old woman after many hospitalizations because of ventricular tachycardia. Clinical, ultrasound and laboratory parameters of Basedow disease. Medication: thiamasole, cortisone and Irenat prepared to the radioiodine therapy. After three times of 20 mCi I131 hypothyroid, 100 μg thyroxin. 48 years old man with hypertrophic cardiomiopathy, after over 6 months use of amiodaron lack of effect and recidive of ventricular tachycardia. Lab. – thyreotoxicosis, in ultrasound left lobe tumor 27 ml, biopsy benign. Initially cured with thiamazole 60 mg, followed with irenat 900 mg daily and after iodine uptake recurrence -20mCi radioiodine 131, euthyreosis after 3 months.

Cases demonstrate problematic situation of amiodaron cured patients, thyroid dysfunction may occur during amiodaron therapy and in some patients is dangerous. Hyperthyroidism is difficult to cure if caused by amiodaron but in this patients should be radical, it is necessary to have available perchlorat for this cases and rodioiodine therapy.