ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Which cytologic or architectural characteristics are associated with malignancy in AUS/FLUS cytologies according to subgroups?
Oya Topaloglu 1 , Aysegul Altinboga 2 , Fatma Neslihan Cuhaci 1 , Cevdet Aydin 1 , Husniye Baser 3 , Omer Yazicioglu 4 , Afra Alkan 5 , Reyhan Ersoy 1 & Bekir Cakir 1
1Department of Endocrinology and Metabolism, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey; 2Department of Pathology, Atatürk Education of Research Hospital, Ankara, Turkey; 3Department of Endocrinology and Metabolism, Atatürk Education of Research Hospital, Ankara, Turkey; 4Department of General Surgery, Atatürk Education and Research Hospital, Ankara, Turkey; 5Department of Biostatistics, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.
Aim: Atypia/follicular lesion of undetermined significance(AUS/FLUS) is a category of thyroid cytology with features that are neither definitely benign or malignant. We aimed to determine whether specific cytologic or architectural features are associated with malignancy in AUS/FLUS category of Bethesda system according to subgroups.
Methods: The specimens of patients who underwent surgery with preoperative thyroid fine neeedle aspiration (FNA) biopsies of Bethesda Category III (AUS/FLUS) were reanalyzed. An experienced cytopathologist who blinded to original cytology and final histopathology was reevaluated the specimens and numerated the cytology from 1 to 7 according to Bethesda system as follows; Group 1: cells producing microfollicles, Group 2: containing predominantly Hurthle cells with rare cells and colloid, Group 3: difficulty in evaluation of atypia due to smear artifacts, Group 4: cellular smears containing benign Hurthle cells, Group 5: focal cells with nuclear changes like papillary carcinoma but generally benign appearance, Group 6: cells with atypic features but generally benign appearance, Group 7: rare follicular cells with nuclear enlargement and frequently apparent nucleoli.
Results: Specimens of one hundred and ninety five patients (153 females, 42 males) with a mean age of 47.87±12.18 years were included to the study. Of these 195 patients, 148 had AUS and 47 had FLUS cytology. Nuclear groove formations are found as higher in malignant group in overall study population and in also AUS subgroup (P=0.005 and P=0.023, respectively), but not in FLUS subgroup (P=0.164). Nuclear enlargement, overlapping, elongation, inclusions, and papilleroid features were similar between malignant and benign groups in all patients, AUS and FLUS subgroups. Furthermore cytologic groups distributions are similar between benign and malignant groups in all patients, and in AUS and FLUS subgroups (P>0.05, for all).
Conclusion: Patients in Bethesda Category III particularly in AUS subgroup with cytologic interpretation of nuclear grooves are at higher risk of malignancy and should undergo surgery.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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