Endocrine Abstracts

Aim: In this study we aimed to evaluate the oxidative stress via evaluating changes in dynamic thiol-disulphide status in euthyroid patients with Hashimoto’s thyroiditis (HT).

Methods: Fifty euthyroid patients with HT and 50 healthy individuals were enrolled in this study. Thyroid function tests (free triiodothyronine (fT3), free thyroxine (fT4), thyrotropin (TSH)), acute phase reactants (C-reactive protein (CRP), high sensitive CRP (hs-CRP)) and thiol-disulphide parameters were evaluated. Native thiol (-SH), total thiol (-SH+-S-S-), disulphide (-S-S-) levels, calculated disulphide/native thiol (-S-S-/-SH), disulphide /total thiol (-S-S-/-SH+-S-S-), native thiol/total thiol (-SH/-SH+-S-S-) ratios were compared between groups.

Results: Mean age was 38.3±10.4 years in the patient group and 37.2±10.1 years in the control group. There were 43 (86%) females and 7 (14%) males in the patient group while there were 39 (78%) females and 11(22%) males in the control group. Median TSH level was significantly higher in the patient group compared to controls (P=0.04). However, fT3 levels were similar statistically between groups (P=0.347), free T4 was significantly lower in the patient group (P=0.01). Mean native thiol and total thiol levels were significantly higher in the patient group compared to the control group (P=0.04 and P=0.036, respectively). There were not any statistically significant differences between groups regarding calculated disulphide/native thiol (-S-S-/-SH), disulphide /total thiol (-S-S-/-SH+-S-S-), native thiol/total thiol (-SH/-SH+-S-S-) ratios. The association between acute phase reactants and thiol-disulphide parameters were evaluated and no significant correlation was found. Similarly, there was no significant correlation between antibody positivity and thiol-disulphide parameters.

Conclusion: To our knowledge, our study is the first one that evaluated the association between HT and thiol-disulphide status according to Erel and Neselioglu method. In conclusion native and total thiol levels were detected to be increased in euthyroid HT patients, these results were not consisted with the literature data using different methods.