Endocrine Abstracts

The research goal was to study serum concentration of immunoregulatory cytokines (IL-1ß, IL-6ß, IL-8ß, IL-10ß) in 80 patients with manifest hypothyroidism at the age of 21–50. 48 patients suffering from chronic autoimmune hypothyroidism and 32 patients with postoperative hypothyroidism were examined. It was revealed that autoimmune hypothyroidism effects balance disturbance of cytokine-producing activity Th1 and Th2 types, this plays an important role in development of autoimmune state, chronization and disease progress. The research goal was to study kidneys’ function in conditions of thyroid hormone deficit. Estimation of kidneys’ function included study of daily microalbuminuria; serum concentration of creatinine and rate calculation of glomerular filtration with MDRD formula; examination of urea level; potassium and natrium in blood serum; urinary excretion of chemokines: monocyte chemoattractant protein-1 (MCP-1) and Regulated on Activation, Normal T-cell Expressed and Secreted. In both groups of patients with hypothyroidism is established a significant decrease of glomerular filtration rate, tubular reabsorption, and increase sodium excretion in the urine, indicating a violation of tubular functions in form of decrease sodium reabsorption in the proximal tubule, and was accompanied by a decrease in median serum sodium levels below the normal range. Level of proinflammatory cytokines IL-1ß, IL-6ß, IL-8ß and anti-inflammatory cytokine IL-10ß; vascular endothelial growth factor in blood serum of 80 patients with clinical hypothyroidism and 50 healthy persons were studied. Our data are the evidence of increase in patients with autoimmune hypothyroidism of IL-6 level of blood serum and urea excretion level of anti-inflammatory cytokine MCP-1, decrease of IL-10 production in patients with clinical hypothyroidism in their second age period. Healthy persons aged over 35 demonstrate increase of level of anti-inflammatory cytokine IL-10 on a background of gently cut cue of proinflammatory cytokines IL-1ß, IL-8ß.