ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Effect of vitamin D supplementation on patients with Graves disease
Maram Maher , Nermin Sheriba , Abeer Elewa , Ahmed Mohamed Bahaa Eldin , Nesma Ali Ibrahim & Dina Marawan
Ain Shams University, Cairo, Egypt.
Multiple factors contribute to the etiology of Graves disease(GD), including genetic and environmental factors.vitamin D is well known in calcium metabolism and has also been shown to be a modulator in innate and adaptive immunity. There is a well-established link between vitamin D deficiency and various autoimmune diseases. The prevalence of vitamin D deficiency was reported to be common in patients with GD. Whether vitamin D deficiency has a causal relationship with GD remains controversial.Aim:to evaluate the effect of vitamin D supplementation in patients with GD with and without opthalmopathy methods: A randomized prospective study was conducted on 60 adult patients with GD.
Group 1: 20 patients with GD receiving 30 mg of methimazole daily.
Group 2: 40 patients with GD receiving same dose of methimazole and vit. D3 200 000 IU/month. Patients were followed up for 3 months.
Results: 40% of patients in group 1 and 72.5% in Group 2 were vit. D deficient,Vit. D was significantly correlated with thyroid volume and degree of exophthalmos. Gp 2 had significant lower thyroid volume and better effect on degree of exopthalomos.
Conclusion: Vit. D suuplementation for GD has a favourable effect on thyroid volume and degree of exophthalmos.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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