Endocrine Abstracts

We present three cases of females with low body weight that needed large amounts of anti-thyroid drugs – 4–5 mg/kg Thiamazole and 50 mg/kg of Propylthiouracil. First patient, aged 32, weight 45 kg, had Graves’s disease evolving for more than five years. She has been proposed surgery and needed 1200 mg/day of Propylthiouracil. She delayed surgery for 2 weeks, then the dosage required for euthyroidism was 1800 mg/day for three weeks. The goitre had 1.2 kg, from mandible angle to the supraclavicular region; she did not develop hypoparathyroidism or palsy of recurent laringeal nerve. Second patient, 47 years old,with Graves’s disease, Addison disease, came with class III heart failure and severe asthma, She required 1800 mg of PTU before surgery and had persistent hypoparathroidism. Third patient, 60 years old had severe cardiomyopathy at the beginning, left ventricle ejection fraction 15%, atrial fibrillation that nedeed Cordarone both intravenously and orally. The dosage was progressivly increased from 60 to 180 mg/day Thyrozol until safely opperated. Patient did not tolerate Propylthiouracil due rash. Ejection fraction became 30% postopperatively and no complications occurred.