ECE2017 Eposter Presentations: Thyroid Thyroid (non-cancer) (260 abstracts)
Correlation between serum nitrite (NO2) levels, TQ7 and GHQ12 questionnaire scores in treatment-naïve hypothyroid patients
Zoran Gluvić 1 , Vladimir Samardzić 1 , Jelena Tica Jevtić 1 , Marina Vujović 1 , Milena Lačković 1 , Vesna Popović-Radinović 1 , Saša Radenković 2 , Violeta Mladenović 3 , Emina Sudar-Milovanović 4 , Milan Obradović 4 & Esma R Isenović 4
1Division of Internal medicine, Department of Endocrinology, Zemun Clinical Hospital, School of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinic for Endocrinology and Diabetes, Nis Clinical Centre, School of Medicine, University of Nis, Nis, Serbia; 3Center for Endocrinology and Diabetes, Clinical Centre Kragujevac, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 4Lab for Molecular Endocrinology and Radiobiology, Institute for Nuclear Sciences ‘Vinča’, University of Belgrade, Belgrade, Serbia.
Introduction: Primary hypothyroidism, as a clinical syndrome caused by insufficiency or inefficacy of thyroid hormones, significantly influences on patients’ quality of life (QoL). Accelerated atherosclerosis induces increased cardiovascular morbidity and mortality rates in hypothyroid patients. Serum NO2 levels, the stable NO metabolites, are among well-known markers for endothelial dysfunction and atherosclerosis in hypothyroidism. We examined the correlation between serum NO2 levels and QoL questionnaires scores (TQ7 and GHQ12) in treatment-naïve hypothyroid females.
Material and methods: Cross-sectional study involved 82 females, divided into three groups according to TSH and fT4 levels: latent (22) and overt (22) hypothyroid, and euthyroid (38) group, respectively. Initially, after informed consent was signed, serum NO2 levels were measured and TQ7 and GHQ12 questionnaires were fulfilled. Obtained data were analysed with appropriate statistical methods. Statistical significance was 0.05.
Results: Overall mean of NO2 level was 11.2 μmol/l (0.9–79.0 μmol/l) and didn’t differ between groups. Mean overall TQ7 and GHQ12 scores were 14 (5–40) and 12 (1–32) respectively, and statistically differ between groups (P<0.01). Correlation between serum NO2 levels and TQ7 and GHQ12 scores didn’t significantly differ (ρNO2/TQ7=−0.241, ρNO2/GHQ12=−0.141; P>0.05).
Conclusions: Decreased serum NO2 levels in hypothyroid groups pointed out to lowered NO bioavailability and therefore endothelial dysfunction. Otherwise, thyroid disease specific questionnaire score determined hypothyroid patients in moderately stressed cluster. A simultaneous use of NO2 levels and QoL scores can alleviate decision to introduce the l-thyroxin management in hypothyroid patients, presumably in latent ones.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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