ECE2017 Eposter Presentations: Thyroid Paediatric endocrinology (5 abstracts)
Age and development stage dependent association between thyroid hormones and growth hormone and linear growth velocity in boys between the age of 1 and 20 years
Afzaal Ahmed Naseem 1 , Mazhar Qayyum 1 , Maleeha Akram 1 , Zubaria Iqbal 1 , Faheem Tahir 2 , Sarwat Jahan 3 , Kiran Afshan 3 & Syed Shakeel Raza Rizvi 1
1Department of Zoology, Pir Mehr Ali Shah Arid Agriculture University Rawalpindi, Rawalpindi/Punjab, Pakistan; 2Reproductive Physiology, Public Health Laboratories Division, National Institute of Health, Islamabad, Pakistan; 3Department of Animal Sciences, Quaid-e-Azam University, Islamabad, Pakistan.
During the time of puberty, thyroid hormones (THs), thyroxin (T4) and triiodothyronine (T3), influence growth and developmental processes by working in association with growth hormone (GH), insulin like growth factor-I (IGF-1), glucocorticoids, insulin and gonadal steroids. THs have a direct effect on GH secretion, which stimulates IGF system. It has been suggested that THs control increase in bone length through synergy with GH. This investigation determined age and developmental stage dependent association between circulating concentrations of T4, T3, GH and linear growth velocity (LGV). Blood samples were collected from 540 normal healthy boys (27 boys/age group) between 1 to 20 years of age and plasma concentrations of T4, T3 and GH were determined using specific ELISA; LGV was measured by calculating changes in height in cm/year. Data were analyzed using Student’s t test, ANOVA and Pearson correlation r. The concentrations of T4 and GH were positively correlated at 3rd, 7–9th, 14–16th and 18th and 19th year. T4 and GH concentrations were positively correlated at pre-puberty and early and late puberty. The concentrations of T4 and LGV were positively correlated at 3rd, 4th, 7th, 14–16th and 18–20th year. There were positive correlations between plasma T4 levels and LGV at pre-puberty and late puberty. There were positive correlations between plasma T3 and GH concentrations at 1st, 3rd, 6th, 7th, 10th-15th and 18th and 19th year. The plasma T3 levels were positively correlated with plasma GH concentrations during infancy, pre-puberty, early and mid-puberty. The concentrations of T3 and LGV were positively correlated at 1st, 3rd, 4th, 7–15th and 18–20th year. The plasma concentrations of T3 were positively correlated with LGV at infancy, pre-puberty, early and mid-puberty. In conclusion, the present study shows negative correlations between T4 and GH and LGV and positive correlations between T3 and GH and LGV at infancy and mid-puberty.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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