Endocrine Abstracts

Several studies have noted that there is a connection between thyroid pathology and breast diseases.

Purpose: The study was undertaken to estimate the frequency of the breasts diseases in adolescent girls with thyroid pathology.

Patients and methods: The study included 2371 girls (aged 10–18 years). Thyroid diseases were diagnosed on the basis of hormonal analysis and typical picture of examination and thyroid ultrasound. Breast diseases were diagnosed on the basis of signs and typical picture of breast ultrasound. We have identified the two groups: girls (n=618) with thyroid pathology (group I) and girls (n=30) without thyroid pathology (control group). Statistical analysis was performed using Mann-Whitney Test, P value of<0.05 were considered statistically significant. This study has been carried out in accordance with the Helsinki Declaration.

Results: The endemic goiter was diagnosed in every forth girls. Autoimmune thyroiditis was found in 30 girls, nodul goiter in 4 and congenital hypothyroidism (later form) in 2 adolescent girls. The investigation shows that every adolescent girl with thyroid diseases had breast disorders. Breast cysts (cystic dysplasia) was diagnosed in 42% cases, fibrous mastopathy (dysplasia) – in 35%, adenosis mastopathy – in 18%, breast secretion – in 5% and fibroadenoma in 4 patients. All girls with breast dysplasia and fibroadenoma complained of mastalgia. The average level on the visual analog pain scale in cases of mastalgia amounted 6.9±2.1 points (in group I). The investigation shows that only 2 girls without thyroid pathology had breast diseases (predmenstrual mastalgia) (<0.001). The average level on the visual analog pain scale in control group was 3.8±1.4 points (P=0.02).

Conclusions: This study has shown a high frequency of the breast diseases among the adolescent girls with thyroid pathology. Thyroid diseases are risk factor for breast disorders and show the necessity of for observation and examination of breast.