ECE2017 Eposter Presentations: Thyroid Clinical case reports - Thyroid/Others (30 abstracts)
Clinicopathological characteristics and outcomes of differentiated thyroid carcinoma in children and adolescents
Andrei Liviu Goldstein 1 , Iulia Andreea Chiriac 1 , Adina Mariana Ghemigian 1, , Camelia Procopiuc 1 , Mircea Vasile Ghemigian 1 , Daniel Brasoveanu 1 , Daniela Goldstein 1 , Mariana Purice 1 , Florin Alexiu 1 , Gabriela Voicu 1 , Dumitru Ioachim 1 & Iuliana Gherlan 1,
1‘C.I.Parhon’ National Institute of Endocrinology, Bucharest, Romania; 2‘Carol Davila’ University of Medicine and Pharmacy, Bucharest, Romania.
Introduction: Differentiated thyroid carcinoma is a rare entity in pediatric population, with particularities in diagnosis, management and outcomes.
Methods, aim: Retrospective noninterventional study describing clinical presentation and outcomes of children with DTC.
Results: Between 2011 and 2017 54 children and adolescents aged 7.8–18 years (mean age at diagnoses 14.4 years) with DTC were diagnosed/followed up in our Institution. The female to male ratio was 3.5:1. In 70% cases unilateral thyroid nodule was the first manifestation of the disease, in 25.9% cases the DTC was diagnosed during the follow-up for chronic thyroid pathology, whereas in 3.7% cases cervical lymph node enlargement was the first clinical sign. 29.6% patients had cervical node involvement at diagnosis, 9.3% had pulmonary metastases. The initial tumour size (over 4 cm diameter), the diffuse sclerosing form of papillary cancer were independent risk factors for initial metastasis. A total thyroidectomy was performed in 58.5% cases, a total thyroidectomy with central neck dissection in 41.5% cases. 57.4% patients were classifies as low risk, 18.6% as high risk patients. The follow-up period was between 1 and 98 month, with an average of 30.4 months. At the last visit 36.3% patients had a good response to therapy, 28.5% were in complete remission of the disease and 9.5% had stable persistent disease.
Conclusion: DTC in children and adolescents has good prognosis even in loco-regionaly advanced forms of the disease.
Volume 49
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Endocrine Abstracts
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