ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Physiological changes of adipokines and selected steroids during the menstrual cycle
Monika Šrámková 1, , Michaela Dušková 1 , Jana Vítků 1 , Josef Včelák 1 , Petr Matucha 1 , Olga Bradnová 1 , Jose Cordeiro 1 & Luboslav Stárka 1
1Institute of Endocrinology, Prague, Czech Republic; 2Faculty Hospital Motol, Prague, Czech Republic.
Context: The cyclical effects of hormones during the menstrual cycle (MC) are responsible for driving ovulation. The information about roles of adipokines within the scope of MC are not definite. Leptin plays a role in sexual function and regulating the onset of puberty. Thin girls often fail to ovulate or release an egg from an ovary during menstruation cycles. Leptin also acts on specific receptors in the hypothalamus to inhibit appetite. Levels of leptin are increased in women suffering from premenstrual syndrome. The aim of our study was to describe physiological changes of selected steroids and adipokines at healthy women during the MC.
Methods: Twenty-seven women with regular menstrual cycles were included in the study, and their hormonal spectrum and adipokines were measured in regular intervals starting from the first day of their MC.
Results: Classical changes in gonadotropins, estrogens and progesterone during the menstrual cycle are accompanied by less striking but significant changes in 17-hydroxyprogesterone and testosterone. No significant changes show dehydroepiandrosterone and its 7-oxygenated metabolites. Adipokines show a tendency to increase during ovulation, while ghrelin and resistin decrease. There is also a remarkable association of sex hormone-binding globulin on the day of the cycle.
Conclusion: Our results demonstrate that changes to adipokines dutiny the menstrual cycle are not substantial, but nonetheless can play a role in the changes of food intake described in the literature. Precise descriptions of physiological changes in healthy women are important in helping us understand the significance of the changes accompanying various pathological states.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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