ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Serum Vitamin D status in women with the polycystic ovary syndrome
Justyna Kuliczkowska-Plaksej 1 , Andrzej Milewicz 1 , Renato Pasquali 2 , Agnieszka Lenarcik-Kabzda 1 , Lukasz Laczmanski 1 , Felicja Lwow 3 , Diana Jedrzejuk 1 & Marek Bolanowski 1
1Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland; 2Department of Medical and Surgical Sciences, Division of Endocrinology, University of Bologna, Bologna, Italy; 3Department of Health Promotion, University School of Physical Education, Wroclaw, Poland.
Objective: To measure the levels of 25-hydroxyvitamin D (25(OH)D) and vitamin D binding protein (VDBP) and assess their relationships with metabolic features in patients with the polycystic ovary syndrome (PCOS).
Methods: 267 women, aged 20–35 years (24.7±4.9): 167 with PCOS, 100 healthy women as a control group were studied. Study groups were divided according to body mass index (BMI). Biochemical and hormonal parameters, 25(OH)D, VDBP were measured. Free and bioavailable 25(OH)D were calculated using the mathematical equations. The percentage of body fat and visceral fat deposit were assessed by DXA.
Results: In the normal weight control group total, free and bioavailable 25(OH)D were significantly (P<0.001 for all) higher than in its overweight/obese counterpart. In women with PCOS both total 25(OH)D (P<0.001), and VDBP (P<0.001) were lower in the overweight/obese subgroups than in the normal weight one. VDPB was negatively correlated with fasting insulin, positively with SHBG in control group. In PCOS group, VDPB was negatively correlated with abdominal fat deposit, BMI, fasting glucose and insulin and positively with HDL and SHBG.
Conclusions: Despite lower total 25(OH)D in obese PCOS women, all women with PCOS (lean and obese) had comparable free and bioavailable 25(OH)D which might be a result of concomitantly lowered serum VDBP levels in obese PCOS women. VDBP might play important role in the regulation of availability of active fractions of 25(OH)D in PCOS women. VDBP is strongly associated with cardio–vascular risk factors such as BMI, waist circumference, visceral fat, fasting insulin in women with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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