ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Novel insulin resistance index using C-peptide is reliable predictor of insulin resistance in women with PCOS
Ivana Bozic-Antic 1 , Dusan Ilic 1 , Jelica Bjekic-Macut 2 , Danijela Vojnovic-Milutinovic 3 , Sanja Ognjanovic 1 , Tamara Bogavac 1 , Bojana Popovic 1 , Tatjana Isailovic 1 , Valentina Elezovic 1 , Olivera Stanojlovic 4 & Djuro Macut 1
1Clinic of Endocrinology, Diabetes and Metabolic Diseases, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2CHC Bezanijska Kosa, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3IBISS, University of Belgrade, Belgrade, Serbia; 4Institute of Physiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.
Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 healthy women (Controls: 22.56±5.46 kg/m2; 28.33±5.62 years). In follicular phase of menstrual cycle total testosterone, SHBG, lipids, glucose, insulin and C-peptide were determined. Novel CIR index (20/(fasting C-peptide×fasting plasma glucose)) and HOMA-IR (fasting plasma glucose× fasting insulin)/22.5 were calculated in all subjects. Euglycaemic hyperinsulinemic clamp (EHC) was performed in PCOS group and the whole body disposal rate (M, mg/kg per min) was determined as the mean of the glucose infusion rate during the last 30 min of EHC. Insulin sensitivity index (M/I) was calculated by dividing M by the steady state plasma insulin level during the last 30 min of EHC. All analyses were adjusted for BMI and age.
Results: In comparison to controls, PCOS had significantly lower CIR index (14.72±2.21 vs 9.65±1.02, respectively; P=0.040) and higher HOMA-IR (2.91±0.36 vs 3.70±0.16, respectively; P=0.047). CIR index strongly correlated with HOMA-IR (ρ=−0.447, P<0.001), M/I (ρ=0.461, P<0.001), BMI (ρ=−0.381, P<0.001) and waist circumference (WC)(ρ=−0.335, P<0.001). HOMA-IR correlated with M/I (ρ=−0.404, P<0.001), BMI (ρ=0.349, P<0.001), WC (ρ=0.348, P<0.001) and, unlike CIR index, also with SHBG (ρ=−0.411, P<0.001).
Conclusion: Novel CIR index could be a good surrogate marker of IR in PCOS. The absence of liver clearance of C-peptide is the reason for stronger correlation of CIR index with M/I in comparison to HOMA-IR.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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