ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Association of basal and post-synacthen stimulated 17-hydroxyprogesterone levels with insulin resistance in polycystic ovary syndrome
Eleni Kandaraki 1 , Georgios Papadakis 2 , Sofia Tsirona 3 , Athina Asimakopoulou 4 , Nikolaos Chiotinis 5 , Genovefa Chronopoulou 5 , Georgia Kassi 4 & Evanthia Diamanti-Kandarakis 3
1Endocrinology Department, Red Cross Hospital, Athens, Greece; 2STEPS Stoffwechselzentrum, Biel/Bienne, Switzerland; 3Department of Endocrinology, Diabetes and Metabolic Diseases, Euroclinic Hospital, Athens, Greece; 43rd Department of Internal Medicine, Endocrinology Unit, Sotiria Hospital, Athens, Greece; 5Biochemical Department, Euroclinic Hospital, Athens, Greece.
Objective: 17-alpha-hydroxyprogesterone caproate therapy during pregnancy has been associated with insulin resistance. The aim of this study was to highlight any possible association of 17OHP with insulin resistance in women with PCOS.
Design: Forty-five women with PCOS underwent 75 g OGTT test and short Synachten test with sampling of stimulated 17OHP. Women were divided into two subgroups according to basal 17OHP cut-off level of 0.8 ng/ml.
Results: Women with basal 17OHP more than 0.8 ng/ml had significantly higher glucose levels at 60′ min: Glu60: 111.36±22.37 mg/dl vs 133.11±32 mg/dl, P=0.047, and at 90′ min Glu90: 93.50±13 mg/dl vs 113.50±27 mg/dl, P=0.038 and more often polycystic ovarian morphology in ultrasound compared to those with basal 17OHP levels below 0.8 ng/ml. The mean percentage increase of 17OHP at 60′ after Synachten test was 223%. According to this, women were subdivided into two categories depending on whether the intraindividual percentage increase of post-Synachten 17OHP levels was higher or lower than the mean percentage increase. A total of 26 women with hyperresponsiveness of 17OHP at 60′ minutes appeared with significant higher insulin resistance and post glucose challenge hyperinsulinemia when compared to 19 women with lower percentage increase of 17OHP, i.e. their mean insulin levels at 30′ minutes were: Ins30: 130.9±98.7 vs 59.3±30.9 μU/ml, P=0.05, at 60′ minutes: Ins60: 182.4±124.9 vs 74.4±32.1 μU/ml, P=0.01, at 90′ minutes: Ins90: 177.2±128.2 vs 67.9±34.1 μU/ml, P=0.01, and at 120′ minutes: Ins120: 121.6±65.2 vs 67.1±45.8 μU/ml, P=0.05.
Conclusions: 17OHP could possibly be related to the metabolic abnormalities in women with PCOS and this should me taken into account especially during pregnancy when insulin resistance increases.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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