Endocrine Abstracts

Previously, we demonstrated that progesterone (P4) could enhance breast cancer cell migration through increasing formation of the p27-RhoA complex and RhoA activation caused by the cSrc/AKT-mediated phosphorylation of p27 at T198. Here, we further examined the effect of P4 on breast cancer cell proliferation. Our results show that P4 (12.5–100 nM) concentration-dependently enhanced proliferation in breast cancer cell lines (T47D and MCF-7). We also found that increases of...

The relationship between the level of genetic variation in CYP17, PSA genes and prostate cancer has been extensively studied but the results are still unclear. A 450c17a (CYP17) polymorphism A1/A2 was described to be significantly associated to prostate cancer. A SNP in the promotor PSA gene is an A to G substitution at position −158 (G158A) was proposed to interact differently with AR, thereby modifying the expression pattern and occurrence of prostate cancer.<p cla...