Endocrine Abstracts

The presence of the enzymes of local metabolism of glucocorticoids in lymphoid organs and many other tissues suggests that the local glucocorticoid signal is not determined only by plasma level of glucocorticoids but also by the local activity of these enzymes. Using resident-intruder test the present study determined if chronic social stress modulates local metabolism of corticosterone and 11-dehydrocorticosterone in rats of Fisher 344 (F344) and Lewis (LEW) strains, which di...