ECE2017 Eposter Presentations: Pituitary and Neuroendocrinology Pituitary - Clinical (145 abstracts)
Is there a role of immunohistochemical expression of pituitary hormones and proliferative marker ki-67 on long-term outcome in our acromegalic patients?
Mustafa Sahin , Caglar Keskin , Saba Kiremitci , Esra Erden , Asena Canpolat , Murat Cinel , Sule Canlar , Ozgur Demir , Sevim Gullu , Rifat Emral , Murat Faik Erdogan , Vedia Gedik , Nilgun Baskal & Demet Corapcioglu
Ankara University School of Medicine endocrinology and Metabolic Diseases Department, Ankara, Turkey.
Expression of hormones other than GH may affect the prognosis in acromegalic patients. Generally, Ki-67 is a well-known proliferative index used to predict remission in pituitary adenomas. We aimed to evaluate the relationship of immunohistochemical expression pituitary hormones, ki-67 and remission. Also we evaluated the role of pre, post-operative clinical and laboratory values, pathological characteristics on long-term remission. We included 64 acromegaly patients that were treated surgically and followed up in our Endocrinology and Metabolic Diseases Department. Demographic, clinical, laboratory and imaging data were collected. We also re-evaluated the immunohistochemistry of all pituitary hormones and ki-67 marker from paraffin blocks. We followed 64 patients (38 women, 26 Male; mean age 46.7±11.8) for 61.8 (6–192) months. We did not found any relationship between remission and multihormonal expression in our patients. We also did not found a significant relationship between ki-67 expression or sex with remission. Early diagnosis age (P=0.045), greater adenoma diameter (P=0.002), low preoperative LH (P=0.036) and high postoperative IGF1 (P<0.0001) only factors that are significantly related with low rate remission. Preoperative cortisol levels are related to ki-67 index level (P=0.004). Low preoperative LH and high postoperative IGF1 levels and tumor diameter may be predictive for remission and low cortisol levels may be predictive for the high ki-67 index.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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