Endocrine Abstracts

The aim: To study the results of researches 35 patients with different pituitary tumours of sellar area, from them men – 17 (48,6%%), women – 18 (51,4%%).

Materials and methods: Depending on sizes there are the adenomas of hypophysis, educed on CT/?RI, patients were up-diffused on two groups: the first group of patients is macroadenomas (from 20 to 30 mm) – 17 (48,6%%), and second group of patients – giant – (more than 30 mm) – 18 (51,4%%).

Results: It was educed, that in 2 groups of patients most often there was panhypopituitarism – at 8 from 18 patients (44,4%%), post-operating panhypopituitarism met – at 10 from 18 patients (55,5%%), while in the 1 group of panhypopituitarism not observed. A bytemporal hemianopsia also with greater frequency was observed for patients 2 groups – 11 supervisions (61,1%%). In addition, secondary amenorrhea met a bowl also for patients 2 groups – 6 (33,3%%). Such violations, as secondary ?steopeniya, endocrine encephalopathy, delay of physical and sexual development were educed only in 2 groups of patients. Thus, the most expressed neuroendocrine and ophthalmology violations met for patients 2 groups. For patients with the giant adenomas of hypophysis the decline of level of STH, FSH is first of all marked, LH (45%%).

Conclusions: From preliminary data of comparative description of sizes of tumour of sellar area and level of STH a tendency took place to that as far as growth size of tumour of the Turkish saddle the basale level of STH of plasma was below. For a receipt the further protracted supervision of data of patients is required of reliable results with an estimation in a dynamics MRI and STH of plasma with realization of loading tests, research of IGF1 and estimation of quality of life for questionnaire of adult growth hormone deficiency (AGDQoL).