Endocrine Abstracts

Introduction: In a recent study, it was determined that morbidity rates due to cardiovascular diseases were affected as a result of long-term follow-up in patients with nonfunctional pituitary adenoma. And cardio/cerebro vascular diseases were the most frequent cause of mortality when mortality rates were examined. In the literature, there are not enough studies evaluating this condition in patients with nonfunctional pituitary adenoma without traditional cardiovascular risk factors. The aim of our study was to determine the peripheral and central blood pressures and arterial stiffness by Pulse Wave Analysis (PWA) in patients with nonfunctional pituitary adenoma without traditional risk factors.

Material & methods: In ourstudy, 60 participants (30 patients with nonfunctional pituitary adenoma and 30 healthy volunteers) without traditional cardiovascular risk factors were evaluated. All participants were similar in terms of gender, age and body mass index. Peripheral and central blood pressure and PWA measurements were performed with a Mobile-O-Graph PWA / ABPM instrument (I.E.M. GmBH, Stolberg, Germany). In the nonfunctional pituitary adenoma group radiological and biochemical data were obtained retrospectively.

Results: In the nonfunctional pituitary adenoma group, systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), central SBP, central DBP, augmentation index that corrected based on pulse rate of 75 bpm (Aix@75) and pulse wave velocity (PWV) were significantly higher than control group. There was no significant correlation between biochemical parameters and arterial stiffness parameters in the group of nonfunctional pituitary adenoma.

Conclusion: Peripheral and central blood pressure and arterial stiffness parameters are negatively affected in patients with nonfunctional pituitary adenoma known as cardiometabolically innocent, without traditional cardiovascular risk factors. Measurement of arterial stiffness in this patient group will lead to early detection of mortality and morbidity due to possible cardiovascular pathologies