Endocrine Abstracts

Objective: To analyze registry data on patients with acromegaly.

Materials and methods: Russian hypothalamic and pituitary tumors registry database (on-line platform), which contains data on 3719 patients with acromegaly.

Results: According to the database, highest prevalence of acromegaly per 100 000 inhabitants is registered in: Penza region (7.3), Kirov region (7.3), Krasnoyarsk region (6.2). Most common clinical presentations in registered acromegalic patients were: headaches (72%) maxillofacial changes (68%), arthralgias (48%) excessive sweating (39%). Information about tumor size was available in 1543 patients: by the time of diagnosis, 516 (33.4%) had pituitary microadenomas and 1027 (66.6%) had macroadenomas. 59.5% of registered patients were prescribed medical therapy: 65.9 and 34.1% were treated with somatostatin receptor ligands (SRL) and dopamine agonists respectively. 29.9% of patients were primarily treated surgically and remaining 10.6% underwent radiotherapy. Remission is registered in 22% cases, 23% of patients have only partial disease control, 41% have an active disease and 14% of records have no data regarding disease state.

Conclusions: Russian hypothalamic-pituitary tumors registry is a promising instrument for epidemiologic and clinical data acquisition. Data suggest that multimodal treatment approach is essential to achieve higher remission rates in patients with acromegaly.