Endocrine Abstracts

Multiple endocrine neoplasia type 1 (MEN 1) is a rare autosomal dominant disease characterized by pancreatic, parathyroid, and anterior pituitary tumours. Hypercalcaemia due to parathyroid tumours is usually the first manifestation. Pancreatic islet tumours occur less frequently, among them gastrinomas and insulinomas are the most prevalent. Insulinomas can be difficult to diagnose. It was not uncommon for patients to have been misdiagnosed with psychiatric illnesses or seizur...

Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited endocrinopathy characterized by tumours of the parathyroid glands, adenohypophyseal and pancreatic tumours. We present a case of a young, 24 years old female patient with a positive familial background for MEN1 (on the fathers’ side of the family). She is one of two sisters with determined heterozigocity of the MEN 1 gene (Exon 2, codon 111). At the age of 12, insulinoma of the head of the pancreas was diagnos...

Introduction: The presentation of a patient with Gigantism, gynaecomastia and increasing height suggests underlying Hypogonadotrophic Hypogonadism. Aetiologies such as a pituitary hamartoma is unlikely.Case study: A 39 year old male presents with a 20 year history of increasing height, shoe size, headaches, sweatiness and gynaecomastia for the past 10 years. He was 2.08 m tall with features in keeping with Acromegaly. He had normal secondary sexual chara...

We report a case of malignant hemangiopericytoma in sellar region in a 73-year-old lady who initially presented with symptomatic hyponatraemia. She was found to have hypocortisolism on short synacthen test. She was treated with hydrocortisone and was found to have secondary hypothyroidism. Her gonadotropin levels were commensurate with menopause, prolactin levels were normal and there was no suggestion of diabetes insipidus. Initial pituitary magnetic resonance imaging (MRI) w...