ECE2017 Eposter Presentations: Interdisciplinary Endocrinology Steroid metabolism + action (5 abstracts)
Reference values for the urinary steroid metabolome: the impact of sex and age on human adult steroidogenesis
Daniel Ackermann 1 , Belen Ponte 2 , Menno Pruijm 3 , Claudia H. d’Uscio 1 , Idris Guessous 4 , Georg Ehret 5 , Fred Paccaud 7 , Antoinette Pechére-Bertschi 6 , Pierre-Yves Martin 2 , Michel Burnier 3 , Bernhard Dick 1 , Bruno Vogt 1 , Murielle Bochud 7 & Nasser A. Dhayat 1
1Department of Nephrology and Hypertension, Bern University Hospital, University of Bern, Bern, Switzerland and Department of Clinical Research, University of Bern, Bern, Switzerland; 2Nephrology Service, Department of Specialties of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland; 3Nephrology Service, University Hospital of Lausanne, Lausanne, Switzerland; 4Department of Community Medicine, Primary Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland; 5Cardiology Service, Department of Specialties of Internal Medicine, University Hospital of Geneva, Geneva, Switzerland; 6Endocrinology Service, Department of Internal Medicine Specialties, University Hospital of Geneva, Geneva, Switzerland; 7Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne, Switzerland.
Background: Urinary steroid metabolomics by GC-MS is an established method in clinic and research to describe steroidogenic disorders, but normative data are scarce.
Methods: The 24-hour urinary excretion of 40 steroid metabolites was measured by GC-MS in 1128 adult participants of the Swiss Kidney Project on Genes in Hypertension (SKIPOGH), a multicenter, family-based, cross-sectional study. Sex- and age-specific reference ranges were created in the units μg/mol Creatinine and μg/24 hours.
Results: Most urinary steroids showed an age- and sex-specificity. An age- but no sex-specificity was found for etiocholanolone, 18-OH-11-dehydro-TH-corticosterone, TH-cortisol, α-cortol, and β-cortol in the unit μg/mol Creatinine. No sex- but an age-specificity was found for 20α-DH-cortisol in μg/24 hours and neither a sex- nor an age-specificity was found for TH-corticosterone and 18-OH-cortisol in μg/24 hours.
Conclusions: Sex- and age-specific reference ranges for 40 steroid metabolites measured by GC-MS were established in a thoroughly characterized general Caucasian population and can be used in routine clinical work.
Volume 49
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Endocrine Abstracts
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