Endocrine Abstracts

Background: Urinary steroid metabolomics by GC-MS is an established method in clinic and research to describe steroidogenic disorders, but normative data are scarce.Methods: The 24-hour urinary excretion of 40 steroid metabolites was measured by GC-MS in 1128 adult participants of the Swiss Kidney Project on Genes in Hypertension (SKIPOGH), a multicenter, family-based, cross-sectional study. Sex- and age-specific reference ranges were created in the unit...

Introduction: It’s assumed that music has health beneficial effects by its potential stres-reducing life. There are some reports that chorists in choral soceity are influenced by music positively during their activities.Research design and methods: 37 healthy volunteers who perform Turkish art music in Bahcesehir Music Society with mean age 50.3±10.3yrs, were included into this study. The state and trait anxiety status of chorists was evaluated...

Impaired 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2)-dependent cortisol inactivation can lead to electrolyte dysbalance, hypertension and cardiometabolic disease. Furthermore, placental 11β-HSD2 essentially protects the fetus from high maternal glucocorticoid levels, and its impaired function has been associated with altered fetal growth and a higher risk for cardio-metabolic diseases in later life. Despite its important role, 11β-HSD2 is not include...

Objective: To determine the intraoperative levels of cortisol and thyroid hormones in surgical patients with different sensitivity to pain.Material and methods: We analyzed the individual sensitivity to pain in 94 people the day before surgery. Patients were ASA 1-2. Age 46±10.2 years. We used a mechanical stimulus (1×5 mm wire with stop) and the visual analogue scale of 10 points (color, grayscale, 10 fields, from light to black). Incentives a...

Introduction: Cushing’s Syndrome secondary to inhaled or topic corticosteroids is very rare, although there are reports of a link to cytochrome inhibitors. Ritonavir, a protease inhibitor used for treatment in human immunodeficiency virus (HIV) infection, is a potent inhibitor of cytochrome P450 3A4.The case: A 41 years old man - with personal history of asthma, HIV infection diagnosed in 2002 and hepatitis C infection since 1999 – was sent to ...