ECE2017 Eposter Presentations: Interdisciplinary Endocrinology Endocrine tumours and neoplasia (9 abstracts)
Chronic stress and somatotroph axis in breast cancer more than a simple association
Iulia Crumpei 1, , Ioana Armasu 1, , Mihai Danciu 1, , Mariana Tofan 3 , Constantin Volovat 3 , Alina Belceanu 1, , Felicia Crumpei 4 , Valentina Adomnicai 2 & Carmen Vulpoi 1,
1University of Medicine and Pharmacy, Iasi, Romania; 2Department of Endocrinology, Sf. Spiridon Hospital, Iasi, Romania; 3Department of Onclogy, Victoria Hospital, Iasi, Romania; 4Department of Radiology, Sf. Spiridon Hospital, Iasi, Romania; 5Department of Morphopathology, Sf. Spiridon Hospital, Iasi, Romania.
Introduction: Epidemiological and clinical studies have proven direct correlations between chronic stress, inflammation and cancer progression. The inflammatory environment preexisting the malignant change and elevated IGF-1 levels are associated with higher cancer risk, especially through GH effects on cell proliferation and inhibition of apoptosis.
Aim: To evaluate the relationship between biological and hormonal stress markers, growth factors and breast cancer (BC).
Patients and Methods: Biological markers (fibrinogen, C-reactive protein (CRP), ESR), endocrine stress markers (urinary free cortisol, ACTH and urinary metanephrines) and somatotroph axis: growth hormone (GH), insulin-like growth factor-1 (IGF1) were determined in a population-based sample of 79 female patients diagnosed and treated for breast cancer.
Results: Among the inflammatory markers the increase of fibrinogen has been connected to high levels of IGF1 (r=0.231, P=0.045), low GH (r=−0.220, P=0.062) and low cortisol (r=−0.226, P=0.058); elevated ESR correlates with the increase in GH secretion (r=0.243, P=0.039) and high CRP was directly linked to higher values of ACTH (r=0.417, P=0.00). Both cortisol (r=−0.265, P=0.025) and urinary metanephrines (r=−0.311, P=0.016) have proven to negatively correlate to IGF-1. While advancing in age, both ACTH levels (r=−0.225, P=0.052) and IGF1 (r=−0.223, P=0.051) tend to decrease.
Conclusion: The chronic inflammatory status, frequently found in patients suffering from breast cancer, seems to be linked to the increase of the endocrine stress and growth markers. This augmentation of IGF1 levels could be a negative predictive factor for the further evolution and prognostic for the disease. However, our study has shown that high levels of stress hormones correlate to lower IGF1.
Volume 49
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