ECE2017 Eposter Presentations: Environment, Society and Governance Endocrine Disruptors (8 abstracts)
Systematic screening for environmental and behavioral determinants identifies factors detrimental to skeletal health
Ling Oei 1, , Joy Wu 3 , Edwin Oei 4 , Fernando Rivadeneira 2, , Andre Uitterlinden 2, , John Ioannidis 6 , Michael Snyder 1 & Chirag Patel 7
1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; 2Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands; 3Division of Endocrinology, Stanford University School of Medicine, Stanford, CA, USA; 4Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands; 5Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands; 6Stanford University School of Medicine, Stanford Prevention Research Center, USA; 7Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Background: An increasing amount of biomedical data is becoming available, and methods are needed to tackle these “big data”.
Methods: We performed a systematic evaluation of 138 environmental and behavioral factors in relation to bone mineral density (BMD) in the National Health and Nutrition Examination Survey (NHANES). Dual energy X-ray absorptiometry (DXA) scans were available for total body, head, pelvis and lumbar spine for 27,259 participants from NHANES surveys 1999–2000 (A), 2001–2002 (B), 2003–2004 (C) and 2005–2006 (D). A discovery Environment-Wide Association Study (EWAS) was performed on cohorts B and D, and replication was sought in cohorts A and C.
Results: Higher serum levels of a-tocopherol (per S.D. β=−0.25% for lumbar spine) and of g-tocopherol (β=−0.54% for total body), forms of vitamin E, were associated with decreased BMD. In contrast, retinol serum levels were related to higher BMD (per S.D. β=+0.21% for total body). Serum lead levels had a negative relationship to BMD of the lumbar spine (per S.D. β=−0.43%) and head (per S.D. β=−0.87%). Higher levels of physical activity were associated with higher BMD (total body: per MET +1.2%). Being a current or past smoker was associated with decreased BMD of the total body, pelvis and head.
Conclusion: In conclusion, our study demonstrates consistently that several behavioral traits and fat-soluble vitamins may have detrimental effects on BMD, while reinforcing the benefit of physical activity for skeletal health.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more