Endocrine Abstracts

In this study, we attempted to assess the toxicity of Methyl Thiophanate (MT) on the biochemical and reproductive parameters in male Wistar rats as well as the possible protective role of Zingiber officinale (Ginger, Ging) extract against MT-induced toxicity. Hence, forty adult Wistar rats were allocated into four groups of 10 rats for each; the first group served as control, groups 2, 3 and 4 were treated orally (5/week) for 8 weeks by MT (150 mg/kg bw), Ging (100 mg/kg bw) and MT plus Ging respectively. At the end of experiment, blood samples were collected under anesthesia for measuring the biochemical parameters and testosterone level, while, the reproductive organs were excised and used for semen quality analysis and histopathological examinations. Results indicated that MT exposure increases the level of blood glucose, cholesterol, triglycerides, urea, uric acid, AST, ALT and total protein, whereas, no clear impact on testosterone level was noted compared to the control. Semen analysis showed a decrease in spermatids number, sperm count, motility and viability. Moreover, a marked histopathological damage in testis and epididymis was detected which reflect a poor semen quality. Ginger extract co-treatment with MT alleviates and/or repairs all adverse toxic effects caused by MT on the reproductive, biochemical and hispathological parameters. This amazing preventive role may be related to its potential antioxidant properties. In conclusion, ginger extract supplementation plays crucial protective role against MT-induced toxicity in male rats.