Endocrine Abstracts

Introduction: Bariatric surgery is currently considered the most effective treatment for morbid obesity, although rates of weight loss and comorbidities resolution differ among bariatric techniques and depending on preoperative factors.

Objectives: In this study we analyse possible factors that influence the outcome of bariatric surgery (weight loss and improvement in metabolic comorbidities) in order to identify those patients most likely to benefit from surgery.

Methods: We included all the patients who underwent bariatric surgery in Hospital Universitario Virgen de la Arrixaca during one year (n=101) of which 62 received LGB and 39 LSG. We retrospectively analysed which preoperative factors were related to percentage of excess body mass index (BMI) loss (%EBMIL), type 2 diabetes remission (T2DM), and higher rates of hypertension (HT) and hypercholesterolemia (Hchol) persistence one year after surgery.

Results: %EBMIL one year after surgery was significantly higher (P=0.016) in patients with preoperative BMI ≤50 kg/m² vs BMI>50 kg/m² (79.4±21.3 vs 65.6±15.4). Age, sex and presurgery T2DM were not associated with %EBMIL one year after surgery. Absence of insulin treatment at baseline (89% vs 50%, P=0.03), less than five years after diagnosis of T2DM (100 vs 53.8% P=0.017) were associated with higher T2DM remission one year post surgery. Age, sex, presurgery BMI, HbA1c and smoking status were not associated with higher remission rates. HT persistence one year after surgery was significantly associated to age >50 (30.3% vs 8.2% P=0.005) and baseline T2DM (30.8% vs 10.3%, P=0.015). HChol persistence one year after surgery was significantly associated to age>50 (28.1% vs 8.5%, P=0.013) and baseline T2DM (28% vs 10.6%, P=0.04). Sex, baseline BMI nor smoking status were not associated with HT nor HChol persistence.

Conclusions: There is a heterogeneous pattern of presurgical factors that predict the outcomes of bariatric surgery.