ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Obesity (81 abstracts)
Impact of weight changes on the incidence of diabetes mellitus: a Korean nationwide cohort study
Eun Sook Kim , Jee Sun Jeong , Kyungdo Han , Mee Kyoung Kim , Seunghwan Lee , Yong-Moon Park , Ki-Hyun Baek , Sung Dae Moon , Je-Ho Han , Ki-Ho Song & Hyuk-Sang Kwon
Catholic University of Korea, Seoul, Republic of Korea.
Objective: Obesity is a well-known risk factor for type 2 diabetes, but few data exist on the association between weight changes and future diabetes risk in non-obese subjects. This study aimed to investigate the effect of weight changes on the incidence of type 2 diabetes in Korea, using prospective nationwide data.
Research design and methods: A total of 51 405 non-diabetic subjects were included who had undergone health examinations in 2002 and completed follow-up in 2006.
Results: Individuals who developed type 2 diabetes were more likely to be older and male, to have high BMI, blood pressure, fasting plasma glucose, and total cholesterol, to be a current smoker, to consume larger amounts of alcohol, to be hypertensive and hyperlipidemic, and to have a family history of diabetes, compared to those without type 2 diabetes. Compared with the consistently non-obese group, there was a higher hazard ratio for incident diabetes (95% confidence interval) in subjects becoming obese (1.50 (1.27–1.78)), losing weight (1.89 (1.61–2.22)), and remaining obese (2.60 (2.56–3.05)), over 4 years, after adjustment for confounding factors. When stratified by BMI categories, risks for incident diabetes were significantly decreased with lower BMI and the trends were more evident in the non-obese group. However, there was no significant association of high BMI with incident diabetes.
Conclusions: Weight loss was significantly associated with decreased diabetes risk both in non-obese and obese Koreans, but particularly in the non-obese. Further long-term studies are needed to establish weight reduction as a preventive strategy for type 2 diabetes.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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