Endocrine Abstracts

The aim: To study efficiency of pathogenetic therapy and dynamics of anthropometric indexes for women with obesity of fertile age at different endocrinopathies to and through 6 months after treatment.

Material and research methods: On the etiologic factor of patient with obesity were up-diffused on three groups: 1 g. are patients with obesity at the polycystic syndrome of ovaries (PCOS) – 30 patients, 2 g. are patients with hypothalamic obesity – 21 cases and 3 g – patient with endocrine obesity (at a primary hypothyroidism) – 20 patients. Age of patients in a 1th group hesitated 39 from 20 to and 28.3±0.64 averaged year. To all patients have been conducted spectrum of investigations, which include clinical, biochemistry, hormonal analysis of the blood. Besides of this, electrocardiography, ultrasound investigation of uteri and ovarium during 11–14 days of periods, and MRY of pituitary. For the 1 g. we administered combination of Syofor 1000 mgs + spironolacton 100 mgs + yodmarinum 100 mgs +L-thyroxine 50 mgs in the morning + antiandrogens + antidepressants. For the 2 group: combination of Syofor 1000 mgs + spironolacton 100 mgs + Yodmarin 100 mgs +L-thyroxine 50 mgs i+ methaboliks + Reduxine (Sibutramin) 15 mgs + antidepressants. For the 3 groups: combination of Yodmarin 100 mgs +L-thyroxine 50 mgs.

The results: In 1 and 2 groups of patients marked reliable decline of BMI 1 and 2 degrees after 6 months of treatment, while for patients 3 groups of reliable changes of BMI through 6 months of treatment were not attained at none of degree of BMI Thus, for patients 1 and 2 groups with BMI 3 degrees through 6 months a tendency was attained to the decline of BMI. In addition, renewal of fecundity and pregnancy was attained for the patients of a 1 group – in 19.5% cases (at 10 patients).

Conclusions: Optimization of treatment of obesity for the women of reproductive age is based on drafting of the individual programs, the choice of that is determined by the values of anthropometric indexes, state of hormonal and metabolic status, features of food behavior and personality-emotional sphere, state of menstrual and reproductive function.