Endocrine Abstracts

Although bariatric surgery has beneficial effects on obesity related complications, rapid weight loss might have negative effects on skeletal health. The objective of our study was to evaluate changes in bone mineral density (BMD) and bone biochemical markers in patients, before and 1 year after bariatric surgery.

Methods: One hundred and two morbidly obese subjects (mean 43±15 years, BMI 48,5 g/cm²) performed either Roux en Y gastric bypass (n:9) or sleeve gastrectomy (n:93) were included in the study. Serum vitamin D, calcium, parathyroid hormone (PTH), C-terminal telopeptide (CTX), osteocalcin levels were measured with immunochemiluminescence method. BMD measured with Dual X ray absorbsiometry (DEXA) before and after first year of the surgery.

Results: BMI decreased significantly after surgery compared to baseline (30,5±8.5kg/m versus 48.5±9.08 P:<0.0001). Serum CTX levels were significantly higher at 1 year (P:<0,0001). Changes in calcium, PTH, 25 OH vitamin D, CTX and osteocalcin at baseline and first year of the surgery. Lumbar BMD was 1,284 versus 1.260 g/cm² (P:0,32), femoral neck BMD was 1.034 versus 1.030 g/cm² (P:0,85), before and after surgery, respectively. We didn’t find any correlation between BMI and BMD but there was a negative correlation between 25-OH D and PTH (r: −0,298 P:0,0003)