Endocrine Abstracts

Introduction: Increased visceral adiposity is usually associated with a clustering of atherogenic risk factors, such as insulin resistance, hypertension, dyslipidemia, alterations in coagulation and inflammatory cytokine profiles. Visceral adipose tissue derived serpin (Vaspin) is an adipokine with insulin sensitizing effect which is markedly elevated in high body mass index (BMI) people.

Aim: To evaluate serum Vaspin level in relation to atherogenic risk factors such as insulin resistance, dyslipidemia, hypertension, inflammation in obese subjects with T2DM and obese subjects without T2DM.

Method: 80 subjects participated, with BMI ranging from 27-39 selected from outpatient clinic of Endocrinology of Ain Shams University Hospital. They were divided into 2 groups 40 obese subjects with T2DM (group I) and 40 obese subjects without T2DM (group II). History, clinical examination, FBS, 2-PP, HBA_1C, Total cholesterol, Triglycerides, HDL and LDL, HOMA/IR, Serum Vaspin level (by ELISA) and CRP were done.

Results: Serum Vaspin was higher in group II than group I (P≤0.01). HOMA-IR was higher in group I than group II (esp. females) with P≤0.01. Regarding hs-CRP there was no significant difference. In Group I serum vaspin had a negative correlation with age (P=0.010), diabetes duration (P=0.015), a positive correlation with Waist/Hip ratio (P=0.047), and LDL (P=0.034). There were no correlation with BMI, systolic blood pressure, diastolic blood pressure, HA1c, fasting blood glucose, 2 HPP, total cholesterol, triglycerides, HDL, hs-CRP and HOMA-IR (P>0.05). In group II, serum vaspin had no correlation with any of the variants (P-value>0.05). Vaspin level was found to be independently correlated with male gender and younger age with (P=0.031).

Conclusion: Obese subjects with T2DM have more atherogenic risk profile and lower Vaspin level than obese subjects without T2DM. It was inversely correlated with age and diabetes duration and positively correlated with Waist/Hip ratio, LDL. Male gender and age are strong independent predictors of serum vaspin level. Vaspin may be an important adepokine that may play an important protective role against metabolic disturbance and cardiovascular risk in obese subjects with T2DM.