ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (95 abstracts)
Testosterone levels in men with diabetes mellitus. What relation?
Nelson Cunha 1 , Leonor Gomes 1, , Diana Martins 1, , Diana Oliveira 1, , Adriana Lages 1 , Mara Ventura 1 , Lúcia Fadiga 1 , Diana Catarino 1 & Francisco Carrilho 1
1Endocrinology, Diabetes and Metabolism Department, University Hospital of Coimbra, Coimbra, Portugal; 2Faculty of Medicine of University of Coimbra, Coimbra, Portugal.
Background: Low serum testosterone (LST) is associated with some chronic diseases, changes in body composition and resistance to insulin. Diabetes is one condition that has high prevalence of LST.
Objetive: To determine the prevalence of LST in men with diabetes and its relationship with age, anthropometric and biochemical data.
Material and methods: A cross-sectional study of 65 men with type 1 and type 2 diabetes was conducted, with age ranging from 25 to 73 years. Clinical data was obtained from clinical records, like disease duration, diary insulin dose, retinopathy, hypertension and medication. Biochemical parameters evaluated were: total testosterone (TT), free testosterone (FT), gonadotropins, prolactin, glycated haemoglobin (A1C), urinary albumin/creatinine relation. LST was considered TT <3.0 ng/ml.
Results: Mean age was 51.9±19.9 years, 60% had type 2 and 40% type 1 diabetes and the mean disease duration was 15.6±10.2 years. 76.9% had body mass index (BMI) ≥25 kg/m2. Twenty-seven patients (41.5%) had LST, 6 (23.1%) in type 1 group and 21 (53.8%) in type 2. In patients under 40 years-old 5 (26.3%) had LST. In multiple linear regression model TT was associated with BMI (β −0.355, P=0.005) and age (β −0.255; P=0.044) and no associations were found with FT. However, patients with FT<15 pg/ml had a significantly higher A1C, 8.40±1.71% vs 7.54±1.38% (P=0.029). BMI ≥25 kg/m2 was associated an increased risk of LST (odds ratio (OR): 6.50; 95% confidence interval (CI) 1.33–31.83), such as antiplatelet medication (OR: 5.83; CI: 1.40–24.23).
Conclusion: In this sample we found a high prevalence of LST in men with diabetes, similar to data described in other studies. Age and BMI were correlated with testosterone levels such as in men without diabetes, and no association was observed with A1C levels. Only FT< 15 pg/ml was associated with higher A1C. To clarify this relation, more data is needed.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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