ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes (to include epidemiology, pathophysiology) (95 abstracts)
The fatty acid profile in diabetic children
Cíntia Castro-Correia 1 , Sara Sousa 2 , Sónia Norberto 3 , Cristina Delerue-Matos 4 , Valentina Domingues 2 , Manuel Fontoura 1 & Conceição Calhau 3,
1Hospital S João – Unidade Endocrinologia Pediátrica, Porto, Portugal; 2Requimte/LAQV-GRAQ – Instituto Superior de Engenharia, Instituto Politécnico do Porto, Porto, Portugal; 3Department of Biochemistry, Faculty of Medicine, University of Porto, Centro de Investigação Médica, Porto, Portugal; 4CINTESIS – Center for Research in Health Technologies and Information Systems, Porto, Portugal.
Several studies have shown a link between pro-inflammatory activity and the presence or relative deficit of some fatty acids. A low amount of omega 3 fatty acids, appears to promote an inflammatory profile. The omega 6 fatty acids have also the same effect. It is well known that a chronic low-grade inflammation is associated to several diseases, namely, diabetes. The follow-up of children and young people with Type 1 diabetes involves the periodic evaluation of their lipidic profile, however it is not done regularly the evaluation of the profile on the concentration of different types of fatty acids.
Objective: To characterize, and compare, fatty acids profile in children with Type 1 diabetes and healthy children.
The authors observed that the ratio of omega 6/omega 3 fatty acids was higher in the control population. Omega 6 levels were higher in the diabetic children compared to the control group. Several other differences in free fatty acid composition were observed.
Conclusion: Our findings showed higher levels of alpha-linolenic acid, EPA and DHA, as well as mono and polyunsaturated fatty acids in diabetic children. This fact is attributed to pharmacological therapy and nutritional management of these children. These findings reinforce the importance of a precocious nutritional attention and intervention in the diabetic child treatment.
Volume 49
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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