ECE2017 Eposter Presentations: Diabetes, Obesity and Metabolism Diabetes complications (102 abstracts)
Markers of nonalcoholic fatty liver disease in patients with diabetes
Irina Savasteeva 1 , Maria Rusalenko 1 , Yulia Yarets 1 , Veronika Selkina 1 , Yana Navmenova 1 , Marina Kaplieva 2 , Alena Makhlina 2 , Tamara Yeudachkova 1 , Elena Vaschenko 1 & Tamara Moskvicheva 1
1Republican Scientific and Practical Center for Radiation Medicine and Human Ecology, Gomel, Belarus; 2Gomel State Medical University, Gomel, Belarus.
Given the significant correlation between the indices of lipid metabolism, liver dimensions, glycated hemoglobin and indicators cytolysis of hepatocytes identified a number of predictors that have had a significant influence on the formation of NAFLD. At a BMI above 26.5 kg/m2, the relative risk (RR) for BMI was 20.02 and was statistically significant (8.25÷48.61). When VLDL level above 0.6 mmol/l relative risk for NAFLD also was statistically significant (RR=28.50; 11.18÷72.65). With increasing levels of triglycerides above 1.43 mmol/l relative risk for NAFLD was 34.69 and was statistically significant (12.68÷94.91). In the course of the factor analysis, we analyzed the contribution of isolated predictors in the development of NAFLD patients with diabetes. So with type 2 diabetes have made the contribution to such predictors as a BMI (65.4%), and increase level of triglycerides (16.85%), while type 1 diabetes - BMI (65.4%) and the level of VLDL (81.0%). In type 2 diabetes the leading influence obesity and atherogenic focus lipogenesis. Patients with type 1 diabetes on the development of obesity affects both NAFLD and associated levels of atherogenic lipids, and the degree of compensation of carbohydrate metabolism and associated level of glycation of proteins.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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