Endocrine Abstracts

The aim: Of the study was to determine the relationship between depression and anxiety symptoms and chronic diabetes complications, disease duration, glycaemic control in type 1 diabetic patients.

Methods: 18–54 year old 215 patients with T1DM were enrolled in the study. Participants filled questionnaires about DM, disease duration, complications and Beck’s depression (DB) and anxiety (BA) inventory. All patients were evaluated for microvascular complications. Laboratory tests: HbA1c, creatinine, albumin in 24 h urine sample were performed.

Results: 124 females (57.67%) and 91 males (42.33%) participated in the study. Cohort consisted of 66 participants with DN (mean age 32.44±6.5 years) and 149 without DN (mean age 31.53±9.99). The group without DN consisted of 53 patients without any complications (mean age 29.49±9.25) and 96 patients with DP and/or DR (mean age 31.07±9.11). The emotional state of females was worse than males (BD: female 9.78±9.07; male 7.51±7.11; P<0.05; BN: female 13.86±9.99; male 8.86±7.79; P<0.01). There was no statistically significant difference between BD among patients with or without complications (P>0.05). There was a statistically significant difference (P=0.04) between BA scores among patients without any complications (N=53, female 31/male 22) (BA 9.42±8.1) and those with DN (N=66, female 36/male 30) (BA 12.05±8.84). The emotional state of patients with longer disease duration (>30 years) (BD 13.59±11.49; BN 15.61±9.79) was worse than patients with shorter one (<10 years) (BD 8.14±8.55; BN 10.86±9.67) (P<0.05). There was nofound statistically significant differencebetween the emotional state and glycaemic control in T1DM patients.

Conclusions: The emotional state of females’ with type 1 diabetes mellitus is worse than males’. Patients with chronic diabetes complications have more anxiety symptoms than those without any complications. Emotional state is worse in diabetics whose disease duration is longer.