Endocrine Abstracts

The development of glomerular hyperfiltration precede the diagnosis of diabetes, but most study had undertaken with diabetes or obesity patients. In this study, we determine the association between glomerular hyperfiltration and other metabolic risk factors which associated diabetes in represent Korean population without chronic kidney disease. We analyzed 19 244 subjects with a estimated glomerular filtration rate(eGFR) above 60 ml/min per 1.73 m² and urine albumin creation ratio (ACR) below 30 mg/g from the 5th (V-2,3, 2011–20012) and 6th (VI-1,2, 2013–2014) Korea National Health and Nutrition Examination Survey (KNHANES). The estimated glomerular filtration rate was calculated on the basis of the CKD-EPI equation. Hyperfiltration was defined as eGFR above the age- and sex-specific 95th percentile for healthy subjects. According to glucose tolerance, the prevalence of hyperfiltration were increased 4.7% in normal, 4.9% in prediabetes, and 5.4% in diabetes (P for trend <0.001). After adjusting age, sex, body weight, hyperfiltration associated with higher body mass index (P<0.001), waist circumference (P<0.001), systolic blood pressure (P=0.003), HbA1c (P=0.039), fasting plasma glucose (P=0.005), triglyceride (P=0.001), energy intake (P=0.001), protein intake (P=0.034), and sodium intake (P=0.002). Hyperfiltration was independently associated with ACR (B=0.053, P<0.001) in multiple regression analysis with above mentioned factors. Higher waist circumference (P<0.001), systolic blood pressure (P<0.001), HbA1c (P<0.001), fasting plasma glucose (P<0.001), and triglyceride (P=0.001) were also independently associated with ACR. In Korean general population, both hyperfiltration and ACR were associated with similar metabolic risk factor and each were independently associated. Longitudinal studies are needed to explore the risk for hyperfiltration and microalbuminuria.